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How to Increase Levels of GDF-11 Naturally: Benefits and Methods

Growth differentiation factor 11 (GDF-11) is a protein that has been linked to numerous health benefits, including improved cardiovascular health, enhanced muscle regeneration, and a decrease in age-related cognitive decline. As we age, our levels of GDF-11 naturally decrease, which is why researchers have been exploring ways to increase GDF-11 levels naturally.

There is evidence which suggest that Growth Differentiation Factor 11 (GDF-11) may be an anti-aging factor, however there is some controversy with some studies suggesting otherwise. This article will discuss ways to boost GDF-11, and is suitable if you are familiar with GDF-11 and convinced of the benefits. If you are interested in learning more about the evidence for and against GDF-11 as an anti-aging treatment you can read more by clicking on this link.

Benefits of GDF-11

GDF-11 is a protein that has been linked to numerous health benefits, including improved cardiovascular health, enhanced muscle regeneration, and a decrease in age-related cognitive decline. It is believed that as we age, our levels of GDF-11 naturally decrease, which is why researchers have been exploring ways to increase GDF-11 levels naturally.

Methods to boost GDF-11 levels

Exercise

Studies have shown that regular exercise can increase GDF-11 levels in the body. Exercise can also have numerous other health benefits, including weight loss, improved heart health, and better mental health.

Caloric restriction

Some studies suggest that caloric restriction may increase GDF-11 levels in the body. Caloric restriction involves consuming fewer calories than your body needs to maintain its weight. It has been shown to increase lifespan in animals and may have similar benefits in humans.

Intermittent fasting

Intermittent fasting involves cycling between periods of eating and fasting. Some studies suggest that intermittent fasting may increase GDF-11 levels in the body, which could potentially lead to numerous health benefits.

Resveratrol

Resveratrol is a compound found in red wine, grapes, and certain berries. Studies have shown that resveratrol may increase GDF-11 levels within older cells in the body, which could potentially lead to numerous health benefits, including improved heart health and a decrease in age-related cognitive decline.

Curcumin

Curcumin is a compound found in turmeric. Studies have shown that curcumin may increase GDF-11 levels in the body, which could potentially lead to numerous health benefits, including improved muscle regeneration and a decrease in age-related cognitive decline.

Vitamin D

Vitamin D deficiency has been linked to a decrease in GDF-11 levels. Therefore, ensuring adequate vitamin D levels may help increase GDF-11 levels in the body.

Conclusion

While research on GDF-11 is still in its early stages, increasing levels of this protein naturally may offer numerous health benefits. By incorporating the methods listed above into your lifestyle, you may be able to increase your GDF-11 levels and potentially improve your cardiovascular health, muscle regeneration, and cognitive function.

Sources

  1. Sinha M, Jang YC, Oh J, et al. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014;344(6184):649-652. doi:10.1126/science.1251152

  2. Katsimpardi L, Litterman NK, Schein PA, et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014;344(6184):630-634. doi:10.1126/science.1251141

  3. Zhang Y, Chen SX, Zhu J, et al. Caloric restriction induces cognitive benefits associated with enhanced GABAergic neurotransmission. EBioMedicine. 2018;37:398-410. doi:10.1016/j.ebiom.2018.10.050

  4. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr. 2007;86(1):7-13. doi:10.1093/ajcn/86.1.7

  5. Guo Y, Darshi M, Ma Y, et al. Mitochondrial retrograde signaling mediated by UCP2 inhibits cancer cell proliferation and tumorigenesis. Cancer Res. 2018;78(13):3255-3268. doi:10.1158/0008-5472.CAN-17-3436

  6. Spaleniak W, Cuendet M. Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289927/

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